Popular weight loss drugs, such as glucagon-like peptide-1 (GLP-1) receptor agonists, may be at higher risk for potentially serious stomach and intestinal issues, compared to people taking a weight loss drug approved in 2014, a large study reveals. 
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GLP-1 receptor agonists, such as Ozempic, Wegovy, and Rybelsus, are a type of injectable medication that works by mimicking the effects of a natural hormone called GLP-1. GLP-1 helps to regulate blood sugar levels and also slows down digestion. This can make people feel fuller for longer and help them to eat less. 
However, slowing down digestion can also lead to digestive problems, such as--
Nausea
Vomiting
Diarrhea
Constipation
Stomach pain
Bloating
Heartburn
Gastroparesis (stomach paralysis)
Pancreatitis (inflammation of the pancreas)
Bowel obstruction
The recent study, which was published in the Journal of the American Medical Association, found that people taking GLP-1 receptor agonists were more likely to experience a variety of digestive problems, including gastroparesis, pancreatitis, and bowel obstruction, compared to people taking bupropion-naltrexone, a different type of weight loss drug.
The researchers noted that the risk of these events was still relatively low, but they said that it is important for people to be aware of the potential side effects of GLP-1 receptor agonists, especially if they have a history of digestive problems.
If you are taking a GLP-1 receptor agonist and experience any digestive problems, be sure to talk to your doctor. They may be able to adjust your dosage or switch you to a different medication.
Here are some tips for reducing your risk of digestive problems while taking a GLP-1 receptor agonist:Start with a low dose and increase gradually as tolerated.
Eat small, frequent meals throughout the day.
Avoid foods that are high in fat, sugar, and fiber.
Drink plenty of fluids.
Tell your doctor about any other medications or supplements you are taking.
If you have any concerns about the side effects of GLP-1 receptor agonists, be sure to talk to your doctor. They can help you to decide if this type of medication is right for you.GLP-1 receptor agonists: Popular weight loss drugs may cause digestive problems
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